{"id":4,"date":"2013-05-29T20:26:37","date_gmt":"2013-05-29T18:26:37","guid":{"rendered":"http:\/\/bioinfo2.ugr.es\/SSinfoSup\/?page_id=4"},"modified":"2015-09-13T18:01:50","modified_gmt":"2015-09-13T16:01:50","slug":"introduccion","status":"publish","type":"page","link":"https:\/\/bioinfo2.ugr.es\/SSinfoSup\/","title":{"rendered":"Overview"},"content":{"rendered":"

Supplementary web page for the paper:<\/p>\n

Pedro Carpena, Jos\u00e9 L. Oliver, Michael Hackenberg, Ana V. Coronado, Guillermo Barturen and Pedro Bernaola-Galv\u00e1n. 2011.\u00a0High-level organization of isochores into gigantic superstructures in the human genome.\u00a0Physical Review E 83: 031908 (1-7)\r\nhttp:\/\/dx.doi.org\/10.1103\/PhysRevE.83.031908<\/pre>\n
Human DNA shows a complex structure with compositional features at many scales; the isochores\u2014long\u00a0DNA segments (~10^5\u00a0bp) of relatively homogeneous guanine+cytosine (G+C) content\u2014are the largest well-documented and well-analyzed compositional structures. However, we report here on the existence of a high-level\u00a0compositional organization of isochores in the human genome. By using a segmentation algorithm incorporating\u00a0the long-range correlations existing in human DNA, we find that every chromosome is composed of a few\u00a0huge segments (~10^7\u00a0bp) of relatively homogeneous G+C content, which become the largest compositional\u00a0organization of the genome. Finally, we show evidence of the biological relevance of these superstructures,\u00a0pointing to a large-scale functional organization of the human genome.<\/p>\n
<\/h3>\n","protected":false},"excerpt":{"rendered":"
Supplementary web page for the paper: Pedro Carpena, Jos\u00e9 L. Oliver, Michael Hackenberg, Ana V. Coronado, Guillermo Barturen and Pedro Bernaola-Galv\u00e1n. 2011.\u00a0High-level organization of isochores into gigantic superstructures in the human genome.\u00a0PhysicalRead More…<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/bioinfo2.ugr.es\/SSinfoSup\/wp-json\/wp\/v2\/pages\/4"}],"collection":[{"href":"https:\/\/bioinfo2.ugr.es\/SSinfoSup\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bioinfo2.ugr.es\/SSinfoSup\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bioinfo2.ugr.es\/SSinfoSup\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bioinfo2.ugr.es\/SSinfoSup\/wp-json\/wp\/v2\/comments?post=4"}],"version-history":[{"count":5,"href":"https:\/\/bioinfo2.ugr.es\/SSinfoSup\/wp-json\/wp\/v2\/pages\/4\/revisions"}],"predecessor-version":[{"id":1518,"href":"https:\/\/bioinfo2.ugr.es\/SSinfoSup\/wp-json\/wp\/v2\/pages\/4\/revisions\/1518"}],"wp:attachment":[{"href":"https:\/\/bioinfo2.ugr.es\/SSinfoSup\/wp-json\/wp\/v2\/media?parent=4"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}